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ea0035oc12.2 | Pituitary Basic | ECE2014

Differential in vitro response to octreotide and pasireotide in normal and tumoral primary pituitary cell cultures

Ibanez-Costa Alejandro , Gahete Manuel David , Jimenez-Reina Luis , Rivero-Cortes Esther , Lopez-Sanchez Laura Maria , Galvez Maria Angeles , de la Riva Andres , Benito-Lopez Pedro , Venegas-Moreno Eva , Angel Japon Miguel , Moreno Alberto , Garcia-Arnes Juan Antonio , Maraver-Selfa Silvia , Angel Arraez Miguel , Leal-Cerro Alfonso , Schmid Herbert A. , Tinahones Francisco J. , Soto-Moreno Alfonso , Castano Justo P. , Luque Raul M.

Somatostatin analogs (SSA) are a first-line treatment for pituitary adenomas (PA). Indeed, multi-receptor targeting SSA such as octreotide and pasireotide are being successfully used to control hormone secretion and/or tumor growth. Unfortunately, many PA escape from SSA-therapy, which could be related to somatostatin receptor (sst) presence, abundance, availability and/or signaling. In order to better define the molecular/cellular features associated to octreotide and pasireo...

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Differential in vitro response to octreotide and pasireotide in normal and tumoral primary pituitary cell cultures

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